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Itaconate alleviates anesthesia/surgery-induced cognitive impairment by activating a Nrf2-dependent anti-neuroinflammation and neurogenesis via intestine-brain axis Xiangyi KongPlasma and brains ended up collected at the end of the study. Baseline teams of naïve (untreated) rTg4510 mice ended up also sacrificed at eight or 12 months of age (n =�

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